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KMID : 0613820060160020302
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Journal of Life Science
2006 Volume.16 No. 2 p.302 ~ p.309
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Relative Biocompatibility Evaluation of Anodized Titanium Specimens in vivo and in vitro
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Lee Yu-Mi
Lee Eun-Jung
Kim Do-Soon
Yee Sung-Tae
Cho Hyun-Wook
Yeom Dong-Sun
Kim Byung-Il
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Abstract
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To evaluate the biocompatibility of untreated and anodized titanium specimens, the specimens were implanted in the subcutaneous tissue of the abdominal region of female mice for two weeks. The reaction of connective tissue to specimens was histologically studied. The implants were encapsulated by fibrous connective tissue consisting of fibroblast, fibrocyte and other cells including neutrophil, macrophage and giant multinucleated cell. Some newly formed blood vessels were located in the fibrous capsule surrounding the implant. Giant multinucleated cells were observed at the fibrous capsule adjacent to the implant. Kind of cell types and the thickness of fibrous capsules were examined quantitatively. Most of cell types located in the fibrous capsule were fibroblast and fibrocyte. The average thickness of fibrous capsules for the anodized specimens was much thinner than that of the untreated titanium specimen. Biocompatibility of titanium specimens were also studied by using cell culture method. The number of MG-63 cells was significantly increased on the anodized titanium specimens in vitro experiment. Our observations suggest that anodized titanium specimens are more effective for the improvement of biocompatibility in vivo and in vitro.
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KEYWORD
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Biocompatibility, anodized titanium, mouse, MG-63 cell
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